Anatomy, Histologyو Embryology
Rahmat allah Fatahian dehkordi; Mohammad Javad Yazdanpanah; Reza Khetvan
Volume 28, Issue 2 , May and June 2021, , Pages 250-258
Abstract
Introduction: The aim of this study was to stereological evaluate of the protective effect of pancreatin on morphological changes in mice kidney after treatment with L-arginine .
Materials and Methods: To conduct research, 50 adult male rats weighing 30±2 gr were divided into 5 groups (equal). ...
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Introduction: The aim of this study was to stereological evaluate of the protective effect of pancreatin on morphological changes in mice kidney after treatment with L-arginine .
Materials and Methods: To conduct research, 50 adult male rats weighing 30±2 gr were divided into 5 groups (equal). In the control group, no administration was made. The pancreatitis induction groups received 2 doses of 300 and 400 mg/100 g body weight of L-arginine. To the induction groups with two different doses, therapeutic drug was prescribed 3.5 pp. of lipase-pancreatin. All treatments were received for 3 consecutive days once a day from L-arginine solution and 72 hours later, a lipase-pancreatin solution was administered to groups of pancreatitis for 20 days .
Results: The results showed that due to experimental pancreatitis, except for medulla volume, decreasing volume of renal cortex, proximal and distal convoluted tubules, and glomeruli was observed in the treated groups compared to the control group. By the administration of pancreatin lipase along with L-arginine, mean volume values of factors such as mean volume of renal cortex, proximal convoluted tubules and glomeruli, have gotten closed to the control group .
Conclusion: According to a final review of the findings, lipasepancreatin solution may be partially effective in mitigating the effects of pancreatitis induced by high doses of L-arginine
Anatomy, Histologyو Embryology
Rahmat allah Fatahian Dehkordi; Kazem Norouzi; Saeed Habibian dehkordi
Volume 28, Issue 1 , January and February 2021, , Pages 30-38
Abstract
Introduction: Diabetes is characterized by high blood glucose levels and defects in insulin production and function. Contamination of food and the environment with lead can worsen the condition of diabetics. This study investigated the effect of thiamine on the small intestinal histomorphology of alloxan-induced ...
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Introduction: Diabetes is characterized by high blood glucose levels and defects in insulin production and function. Contamination of food and the environment with lead can worsen the condition of diabetics. This study investigated the effect of thiamine on the small intestinal histomorphology of alloxan-induced diabetic rats. Material and Methods: In this interventional study, 63 Wistar rats were randomly divided into 9 groups. Three groups of animals were considered as control group (A), thiamine+lead 200 (H) and thiamine+lead 1000 (I). Lead in ppm and acetate form was added to drinking water. The other groups became diabetic via alloxan at a dose of 200 mg/kg. Group B: diabetic mice; Group C: Diabetic mice receiving thiamine; Groups D and E of diabetic mice receiving lead 200 and 1000 were named. Mice in groups F and G received 200 and 1000 ppm of thiamine and lead. Thiamine was used daily and peritoneal with 70 mg/kg dose. On the 29th day, histotechnique was performed on small intestine samples and their histomorphometry was examined. Result: Histomophometry of intestinal structure in mice receiving untreated lead in diabetic group showed a significant increase compared to healthy mice. However, these parameters did not show a significant difference in lead-receiving diabetic rats treated with thiamine compared to the control group. The thiamin improved insulin secretion and reduced turbulence in villi´s of small intestine and improve size of muscular layer in digestive lumen. Conclusion: Probably the antioxidant compound in the thiamin can reduce some complications of lead acetate in diabetic patients.